2021 was the fifth Little Cinema & Galway City of Film 48 Hour Challenge, and it was the second Challenge to take place virtually, during Lockdown. Teams again took part remotely around the country.

The Best Film Award went to Hardback Films & Co, with their film Whale Fall, captained by Katie McNiece.

Other awards as judged by a team of industry professionals were as followed:

Best Film – Whale Fall – Hardback Films
Best Cinematography – Mijrin Al Hajri – Interviewing Lance Masterson
Best Editing – Katie McNiece – Whale Fall
Best Actor – Paul Fitzgerald – No Strings Attached
Best Actress – Rebecca Hickey – Whale Fall
Best Special – FX Barry Fahy – No Strings Attached
Best Line – Barry Fahy – No Strings Attached
Best Prop – Vera Kilgallon – This Time